Hybrid fitness competitions such as HYROX have rapidly gained popularity, blending aerobic endurance running with a variety of high-intensity resistance and ergometer-based stations in a globally standardized format. The sport’s unique structure, comprising eight 1-kilometer runs interspersed with diverse workload stations, presents distinct physiologic, biomechanical, and technical demands. This review synthesizes existing research on hybrid fitness events to identify the key determinants of HYROX performance, emphasizing aerobic capacity, anaerobic power, local muscular endurance, and maximal strength. The aerobic system is foundational, enabling recovery between high-intensity efforts and sustaining performance during the event’s prolonged duration. Conversely, anaerobic capacity is critical for executing the high-intensity efforts demanded by each fitness station. Local muscular endurance supports repeated submaximal contractions, while strength and power underpin performance in movements such as sled pushes and running economy. Technical proficiency and injury prevention strategies are also discussed, alongside targeted programming recommendations, including high-intensity interval training, circuit training, and blood flow restriction methods. Despite its growing popularity, limited sport-specific research exists, necessitating further investigation to refine training and performance strategies. This review provides a comprehensive framework for athletes and coaches to optimize preparation and performance in HYROX, contributing to the broader understanding of hybrid fitness competitions.

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